请使用支持JavaScript的浏览器!
主营:抗癌化学试剂和激酶抑制剂
banner
当前位置: 首页 > 产品中心 > Angiogenesis > MedKoo/PD-173955featured/5mg/406164

MedKoo/PD-173955featured/5mg/406164

  • 产品编号: 406164
  • 美  元  价: $350.00
  • 市  场  价: ¥7000.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: MedKoo Biosciences, Inc
  • 产品分类:
  • 公司分类: Angiogenesis
MedKoo/PD-173955featured/5mg/406164
  • MedKoo/PD-173955featured/5mg/406164
商品介绍

PD-173955
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406164

CAS#:260415-63-2

Description:PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.

Price and Availability

SizePriceShipping out timeQuantity
5mgUSD 3502 Weeks
10mgUSD 5502 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

PD173955, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 406164Name: PD-173955CAS#: 260415-63-2Chemical Formula: C21H16Cl2N4OSExact Mass: 442.04219Molecular Weight: 443.34894Elemental Analysis: C, 56.89; H, 3.64; Cl, 15.99; N, 12.64; O, 3.61; S, 7.23

Synonym:PD173955; PD 173955; PD173955.

IUPAC/Chemical Name:6-(2,6-dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key:VAARYSWULJUGST-UHFFFAOYSA-N

InChi Code:InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)

SMILES Code:O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=CC(SC)=C4)N=C3N1C

Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Kraus GA, Gupta V, Mokhtarian M, Mehanovic S,Nilsen-Hamilton M. New effective inhibitors of the Abelson kinase.Bioorg Med Chem. 2010 Sep 1;18(17):6316-21. doi:10.1016/j.bmc.2010.07.021. Epub 2010 Jul 14. PubMed PMID: 20674368.

2: Sylvester JE, Kron SJ. A bead-based activity screen forsmall-molecule inhibitors of signal transduction in chronic myelogenousleukemia cells. Mol Cancer Ther. 2010 May;9(5):1469-81. doi:10.1158/1535-7163.MCT-10-0157. Epub 2010 Apr 27. PubMed PMID: 20423990;PubMed Central PMCID: PMC2868067.

3: Crespo A, Fernández A. Induced disorder in protein-ligand complexesas a drug-design strategy. Mol Pharm. 2008 May-Jun;5(3):430-7. doi:10.1021/mp700148h. Epub 2008 Feb 16. Erratum in: Mol Pharm. 2008Jul-Aug;5(4):680. Mol Pharm. 2010 Feb 1;7(1):306. Mol Pharm. 2010 Oct4;7(5):1877. PubMed PMID: 18278867.

4: Gunby RH, Ahmed S, Sottocornola R, Gasser M, Redaelli S, Mologni L,Tartari CJ, Belloni V, Gambacorti-Passerini C, Scapozza L. Structuralinsights into the ATP binding pocket of the anaplastic lymphoma kinaseby site-directed mutagenesis, inhibitor binding analysis, and homologymodeling. J Med Chem. 2006 Sep 21;49(19):5759-68. PubMed PMID: 16970400.

5: Caligiuri M, Molz L, Liu Q, Kaplan F, Xu JP, Majeti JZ, Ramos-KelseyR, Murthi K, Lievens S, Tavernier J, Kley N. MASPIT: three-hybrid trapfor quantitative proteome fingerprinting of small molecule-proteininteractions in mammalian cells. Chem Biol. 2006 Jul;13(7):711-22.PubMed PMID: 16873019.

6: Verkhivker GM. Imprint of evolutionary conservation and proteinstructure variation on the binding function of protein tyrosine kinases.Bioinformatics. 2006 Aug 1;22(15):1846-54. Epub 2006 May 23. PubMedPMID: 16720585.

7: Liu L, D"Mello SR. Phosphorylation of IkappaB-beta is necessary forneuronal survival. J Biol Chem. 2006 Jan 20;281(3):1506-15. Epub 2005Nov 11. PubMed PMID: 16286457.

8: O"Hare T, Pollock R, Stoffregen EP, Keats JA, Abdullah OM, MosesonEM, Rivera VM, Tang H, Metcalf CA 3rd, Bohacek RS, Wang Y,Sundaramoorthi R, Shakespeare WC, Dalgarno D, Clackson T, Sawyer TK,Deininger MW, Druker BJ. Inhibition of wild-type and mutant Bcr-Abl byAP23464, a potent ATP-based oncogenic protein kinase inhibitor:implications for CML. Blood. 2004 Oct 15;104(8):2532-9. Epub 2004 Jul15. PubMed PMID: 15256422.

9: Cowan-Jacob SW, Guez V, Fendrich G, Griffin JD, Fabbro D, Furet P,Liebetanz J, Mestan J, Manley PW. Imatinib (STI571) resistance inchronic myelogenous leukemia: molecular basis of the underlyingmechanisms and potential strategies for treatment. Mini Rev Med Chem.2004 Mar;4(3):285-99. Review. PubMed PMID: 15032675.

10: Strife A, Wisniewski D, Liu C, Lambek CL, Darzynkiewicz Z, SilverRT, Clarkson B. Direct evidence that Bcr-Abl tyrosine kinase activitydisrupts normal synergistic interactions between Kit ligand andcytokines in primary primitive progenitor cells. Mol Cancer Res. 2003Jan;1(3):176-85. PubMed PMID: 12556557.

品牌介绍


MedKoo是世界领先的供应商之一的抗癌化学试剂和激酶抑制剂。我们制造、销售和分发高质量的抗癌小分子肿瘤学研究试剂。我们的使命是建立世界上最全面的抗癌小分子的集合。我们也为医药行业提供高质量的研究服务、医学研究机构和学术机构。我们致力于提供优质的服务。

MedKoo是世界领先的供应商之一的抗癌化学试剂和激酶抑制剂。我们制造、销售和分发高质量的抗癌小分子肿瘤学研究试剂。我们的使命是建立世界上最全面的抗癌小分子的集合。我们也为医药行业提供高质量的研究服务、医学研究机构和学术机构。我们致力于提供优质的服务和分子有竞争力的价格。MedKoo是您可靠的合作伙伴采购药物发现和药物分子。




蚂蚁淘(ebiomall)作为一家生命科学领域的垂直电商平台,公司专注生物医学科研用品的全球导购和品牌推广,为海内外厂方与代理经销商搭建跨境贸易系统和交流平台。产品齐全,200+分类,1000+品牌,500万+产品信息。100%正品,专业售后,到货快,在线下单, 简单轻松,节省科学家宝贵的科研时间。为您竭诚服务!

【订购】蚂蚁淘生物科技  联系方式:4000-520-616

更多产品,更多优惠!请联系我们!

苏州蚂蚁淘生物科技有限公司

免费热线:4000-520-616

官网:https://www.ebiomall.cn/



MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
自营商城图标
厂家直采
全球直采模式 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔
在线客服
客服电话

4000-520-616

0512-67156496