AZD-4547

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WARNING: This product is for research use only, not for human or veterinary use.

Description:AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.

Price and Availability

AZD-4547, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 204550Name: AZD-4547CAS#: 1035270-39-3Chemical Formula: C26H33N5O3Exact Mass: 463.25834Molecular Weight: 463.57192Elemental Analysis:C, 67.36; H, 7.18; N, 15.11; O, 10.35

Related CAS #:1035270-39-31394854-62-6

Synonym:AZD4547; AZD-4547; AZD 4547.

IUPAC/Chemical Name:N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

InChi Key:VRQMAABPASPXMW-HDICACEKSA-N

InChi Code:InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+

SMILES Code:O=C(NC1=NNC(CCC2=CC(OC)=CC(OC)=C2)=C1)C3=CC=C(N4C[C@H](C)N[C@H](C)C4)C=C3

Technical Data

Additional Information

Related CAS#Sci-Finder listed CAS#1394854-62-6for AZD-4547ChemIDplus listed CAS#1035270-39-3 for AZD-4547, see website: https://chem.nlm.nih.gov/chemidplus/rn/1035270-39-3 According to Sci-Finder, Chemical name for CAS#1394854-62-6:N-[3-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl]-4-(3,5-dimethyl-1-piperazinyl)benzamideChemical name for CAS#1035270-39-3:rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide

References

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8: Chell V, Balmanno K, Little AS, Wilson M, Andrews S, Blockley L,Hampson M, Gavine PR, Cook SJ. Tumour cell responses to new fibroblastgrowth factor receptor tyrosine kinase inhibitors and identification ofa gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.Oncogene. 2013 Jun 20;32(25):3059-70. doi: 10.1038/onc.2012.319. Epub2012 Aug 6. PubMed PMID: 22869148.

9: Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM,Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, RiccardiR, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T,Finocchiaro G, Lasorella A, Rabadan R, Iavarone A. Transforming fusionsof FGFR and TACC genes in human glioblastoma. Science. 2012 Sep7;337(6099):1231-5. doi: 10.1126/science.1220834. Epub 2012 Jul 26.PubMed PMID: 22837387; PubMed Central PMCID: PMC3677224.

10: Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S,Rooney C, Coleman T, Baker D, Mellor MJ, Brooks AN, Klinowska T.AZD4547: an orally bioavailable, potent, and selective inhibitor of thefibroblast growth factor receptor tyrosine kinase family. Cancer Res.2012 Apr 15;72(8):2045-56. doi: 10.1158/0008-5472.CAN-11-3034. Epub 2012Feb 27. PubMed PMID: 22369928.