AAE871

WARNING: This product is for research use only, not for human or veterinary use.

Description:AAE871 is a type I FLT3 inhibitor.

Price and Availability

AEE871, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406213Name: AAE871CAS#: 289479-07-8Chemical Formula: C24H34N8O2SExact Mass: 498.25254Molecular Weight: 498.64Elemental Analysis: C, 57.81; H, 6.87; N, 22.47; O, 6.42; S, 6.43

Synonym:AAE871; AAE-871; AAE 871.

IUPAC/Chemical Name:N2-((1r,4r)-4-aminocyclohexyl)-9-ethyl-N6-(4-(piperidin-1-ylsulfonyl)phenyl)-9H-purine-2,6-diamine

InChi Key:IUUNTNJCKSXDOW-UAPYVXQJSA-N

InChi Code:InChI=1S/C24H34N8O2S/c1-2-31-16-26-21-22(29-24(30-23(21)31)28-19-8-6-17(25)7-9-19)27-18-10-12-20(13-11-18)35(33,34)32-14-4-3-5-15-32/h10-13,16-17,19H,2-9,14-15,25H2,1H3,(H2,27,28,29,30)/t17-,19-

SMILES Code:O=S(C1=CC=C(NC2=C3N=CN(CC)C3=NC(N[C@H]4CC[C@H](N)CC4)=N2)C=C1)(N5CCCCC5)=O

Technical Data

Additional Information

References

1:  Ellen Weisberg, Johannes Roesel, PascalFuret, Guido Bold, Patricia Imbach, Andreas Flörsheimer, GeorgioCaravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin.Antileukemic Effects of Novel First- and Second-Generation FLT3Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October;1(10): 1021–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267