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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/9-hydroxyellipticine HClfeatured/100mg/406583
产品编号:406583
市  场 价:¥25000.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
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美  元  价:$1250.00
品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
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MedKoo/9-hydroxyellipticine HClfeatured/100mg/406583
商品介绍

9-hydroxyellipticine HCl
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406583

CAS#:52238-35-4 (HCl)

Description:9-hydroxyellipticine, also known asIGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines.

Price and Availability

SizePriceShipping out timeQuantity
100mgUSD 12502 Weeks
200mgUSD 19502 Weeks
500mgUSD 24502 Weeks
1gUSD 32502 Weeks
2gUSD 46502 Weeks
5gUSD 72502 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

9-hydroxyellipticine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406583Name: 9-hydroxyellipticine HClCAS#: 52238-35-4 (HCl)Chemical Formula: C17H14N2OExact Mass: 262.11061Molecular Weight: 262.31Elemental Analysis:C, 68.34; H, 5.06; Cl, 11.87; N, 9.38; O, 5.35

Related CAS #:51131-85-2 (free base)52238-35-4 (HCl)58447-24-8 (methiodide).

Synonym:9-hydroxyellipticine HCl; 9-hydroxyellipticine hydrochloride; Hydroxyellipticine; 9-Hydroxyellipticin; NSC 210717;IGIG 929; IGIG929; IGIG-929; LS133324; LS-133324; LS 133324.

IUPAC/Chemical Name:5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol hydrochloride

InChi Key:DLDKVFOKLGPVBT-UHFFFAOYSA-N

InChi Code:InChI=1S/C17H14N2O.ClH/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17;/h3-8,19-20H,1-2H3;1H

SMILES Code:OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1.[H]Cl

Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Harding MM, Grummitt AR. 9-hydroxyellipticine andderivatives as chemotherapy agents. Mini Rev Med Chem. 2003Mar;3(2):67-76. Review. PubMed PMID: 12570841.

2: Saeki K, Obi I, Ogiku N, Shigekawa M, Imagawa T, Matsumoto T.Cardioprotective effects of 9-hydroxyellipticine on ischemia andreperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8.PubMed PMID: 12083739.

3: Sugikawa E, Tsunoda S, Nakanishi N, Ohashi M. 9-Hydroxyellipticinealters the conformation and DNA binding characteristics of mutated p53protein. Anticancer Res. 2001 Jul-Aug;21(4A):2671-5. PubMed PMID:11724337.

4: Mizumoto K, Sato N, Kusumoto M, Niiyama H, Maehara N, Nishio S, Li Z,Ogawa T, Tanaka M. Diverse effects of 9-hydroxyellipticine on thechemosensitivity of human pancreatic cancer cells harboring p53mutations. Cancer Lett. 2000 Feb 28;149(1-2):85-94. PubMed PMID:10737712.

5: Sugikawa E, Hosoi T, Yazaki N, Gamanuma M, Nakanishi N, Ohashi M.Mutant p53 mediated induction of cell cycle arrest and apoptosis at G1phase by 9-hydroxyellipticine. Anticancer Res. 1999Jul-Aug;19(4B):3099-108. PubMed PMID: 10652599.

6: Khélifa T, René B, Le Mée S, Lambert B, Saucier JM, Markovits J,Jacquemin-Sablon H, Jacquemin-Sablon A. Transfection of9-hydroxyellipticine-resistant Chinese hamster fibroblasts with humantopoisomerase IIalpha cDNA: selective restoration of the sensitivity toDNA religation inhibitors. Cancer Res. 1999 Oct 1;59(19):4927-36. PubMedPMID: 10519406.

7: Sato N, Mizumoto K, Kusumoto M, Niiyama H, Maehara N, Ogawa T, TanakaM. 9-Hydroxyellipticine inhibits telomerase activity in human pancreaticcancer cells. FEBS Lett. 1998 Dec 18;441(2):318-21. PubMed PMID:9883907.

8: Ismail MA, Sanders KJ, Fennell GC, Latham HC, Wormell P, Rodger A.Spectroscopic studies of 9-hydroxyellipticine binding to DNA.Biopolymers. 1998 Sep;46(3):127-43. PubMed PMID: 9741963.

9: Elcock AH, Rodger A, Richards WG. Theoretical studies of theintercalation of 9-hydroxyellipticine in DNA. Biopolymers. 1996Sep;39(3):309-26. PubMed PMID: 8756512.

10: Ohashi M, Sugikawa E, Nakanishi N. Inhibition of p53 proteinphosphorylation by 9-hydroxyellipticine: a possible anticancermechanism. Jpn J Cancer Res. 1995 Sep;86(9):819-27. PubMed PMID:7591958.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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