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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/AC17/1/406291
产品编号:406291
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
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美  元  价:待定
品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
公司分类:
MedKoo/AC17/1/406291
商品介绍

AC17

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406291

CAS#:51460-26-5

Description:AC17, a novel 4-arylidene curcumin analog, is a potent 19S deubiquitinase inhibitors with great potential for anticancer drug development. AC17 serves as an irreversible deubiquitinase inhibitor of 19S RP, resulting in inhibition of NF-κB pathway and reactivation of proapoptotic protein p53. In addition, in a murine xenograft model of human lung cancer A549, treatment with AC17 suppresses tumor growth in a manner associated with proteasome inhibition, NF-κB blockage, and p53 reactivation.

Price and Availability

SizePriceShipping out timeQuantity
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

AC17, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406291Name: AC17CAS#: 51460-26-5Chemical Formula: C31H30O8Exact Mass: 530.19407Molecular Weight: 530.57Elemental Analysis: C, 70.18; H, 5.70; O, 24.12

Synonym:AC17; 4arylidene curcumin;

IUPAC/Chemical Name:(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione

InChi Key:AYIYVEPNEPUJCF-GNXRPPCSSA-N

InChi Code:InChI=1S/C31H30O8/c1-35-27-14-9-20(17-30(27)38-4)6-11-24(32)23(16-22-8-13-26(34)29(19-22)37-3)25(33)12-7-21-10-15-28(36-2)31(18-21)39-5/h6-19,34H,1-5H3/b11-6+,12-7+

SMILES Code:O=C(/C(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)=C/C2=CC=C(O)C(OC)=C2)/C=C/C3=CC=C(OC)C(OC)=C3

Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Zhou B, Zuo Y, Li B, Wang H, Liu H, Wang X, Qiu X,Hu Y, Wen S, Du J, Bu X. Deubiquitinase Inhibition of 19S Regulatory Particles by 4-ArylideneCurcumin Analog AC17 Causes NF-κB Inhibition and p53 Reactivation in Human LungCancer Cells. Mol Cancer Ther. 2013 Aug;12(8):1381-92. doi: 10.1158/1535-7163.MCT-12-1057. Epub 2013 May 21. PubMed PMID: 23696216.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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