MedKooCat#:206032
Name:Gandotinib(LY2784544)
CAS#:1229236-86-5
ChemicalFormula:C23H25ClFN7O
ExactMass:469.17931
MolecularWeight:469.94
ElementalAnalysis:C,58.78;H,5.36;Cl,7.54;F,4.04;N,20.86;O,3.40
Synonym:LY2784544;LY2784544;LY-2784544;Gandotinib.
IUPAC/ChemicalName:3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
InChiKey:SQSZANZGUXWJEA-UHFFFAOYSA-N
InChiCode:InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h4-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
SMILESCode:CC1=NNC(NC2=NN3C(C(CN4CCOCC4)=C2)=NC(C)=C3CC5=CC=C(Cl)C=C5F)=C1
LY2784544haspotentialfordevelopmentasatargetedagentagainstJAK2V617FandmayhavepropertiesthatallowsuppressionofJAK2V617F-inducedMPNpathogenesiswhileminimizingeffectsonhematopoieticProgenitorcells.LY2784544iscurrentlyunderclinicaltrialsforparticipantswithmyeloproliferativeneoplasms.
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