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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/LB42708featured/5mg/406418
产品编号:406418
市  场 价:¥5000.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$250.00
品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
公司分类:
MedKoo/LB42708featured/5mg/406418
商品介绍

LB42708
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406418

CAS#:226929-39-1

Description:LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation.

Price and Availability

SizePriceShipping out timeQuantity
5mgUSD 2502 Weeks
10mgUSD 4002 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

LB42708, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS docum ents are available in one week after order is received.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406418Name: LB42708CAS#: 226929-39-1Chemical Formula: C30H27BrN4O2Exact Mass: 554.13174Molecular Weight: 555.46Elemental Analysis: C, 64.87; H, 4.90; Br, 14.39; N, 10.09; O, 5.76

Synonym:LB42708; LB-42708; LB 42708.

IUPAC/Chemical Name:(1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone

InChi Key:GUUIRIMAQGOLHT-UHFFFAOYSA-N

InChi Code:InChI=1S/C30H27BrN4O2/c31-24-10-8-22(9-11-24)17-35-21-32-16-25(35)18-33-19-28(27-7-3-5-23-4-1-2-6-26(23)27)29(20-33)30(36)34-12-14-37-15-13-34/h1-11,16,19-21H,12-15,17-18H2

SMILES Code:O=C(C1=CN(CC2=CN=CN2CC3=CC=C(Br)C=C3)C=C1C4=C5C=CC=CC5=CC=C4)N6CCOCC6

Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Moorthy NS, Sousa SF, Ramos MJ, Fernandes PA.Farnesyltransferase inhibitors: a comprehensive review based onquantitative structural analysis. Curr Med Chem. 2013;20(38):4888-923.PubMed PMID: 24059235.

2: Kim CK, Choi YK, Lee H, Ha KS, Won MH, Kwon YG, Kim YM. Thefarnesyltransferase inhibitor LB42708 suppresses vascular endothelialgrowth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activatedprotein kinase and phosphatidylinositol 3-kinase/Akt signal pathways.Mol Pharmacol. 2010 Jul;78(1):142-50. doi: 10.1124/mol.110.063586. Epub2010 Apr 20. PubMed PMID: 20406854.

3: Kim HS, Kim JW, Gang J, Wen J, Koh SS, Koh JS, Chung HH, Song SY. Thefarnesyltransferase inhibitor, LB42708, inhibits growth and inducesapoptosis irreversibly in H-ras and K-ras-transformed rat intestinalepithelial cells. Toxicol Appl Pharmacol. 2006 Sep 15;215(3):317-29.Epub 2006 May 19. PubMed PMID: 16712893.

4: Na HJ, Lee SJ, Kang YC, Cho YL, Nam WD, Kim PK, Ha KS, Chung HT, LeeH, Kwon YG, Koh JS, Kim YM. Inhibition of farnesyltransferase preventscollagen-induced arthritis by down-regulation of inflammatory geneexpression through suppression of p21(ras)-dependent NF-kappaBactivation. J Immunol. 2004 Jul 15;173(2):1276-83. PubMed PMID:15240720.

5: Kim KW, Chung HH, Chung CW, Kim IK, Miura M, Wang S, Zhu H, Moon KD,Rha GB, Park JH, Jo DG, Woo HN, Song YH, Kim BJ, Yuan J, Jung YK.Inactivation of farnesyltransferase and geranylgeranyltransferase I bycaspase-3: cleavage of the common alpha subunit during apoptosis.Oncogene. 2001 Jan 18;20(3):358-66. PubMed PMID: 11313965.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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