SL327

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WARNING: This product is for research use only, not for human or veterinary use.

Description:SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization.

Price and Availability

SL327, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. Delivery time: overnight (USA/Canada); 3-5 days (worldwide). Shipping fee: from $30.00 (USA); from $45.00 (Canada); from $70.00 (international).

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406197Name: SL327CAS#: 305350-87-2Chemical Formula: C16H12F3N3SExact Mass: 335.0704Molecular Weight: 335.35Elemental Analysis: C, 57.31; H, 3.61; F, 17.00; N, 12.53; S, 9.56

Synonym:SL327; SL 327; SL-327.

IUPAC/Chemical Name:(E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile

InChi Key:JLOXTZFYJNCPIS-SQFISAMPSA-N

InChi Code:InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13-

SMILES Code:N#C/C(C1=CC=CC=C1C(F)(F)F)=C(N)/SC2=CC=C(N)C=C2

Technical Data

Additional Information

References

1: Longoni R, Spina L, Vinci S, Acquas E. The MEKinhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned placeaversion: a behavioral and immunohistochemical study. Psychopharmacology (Berl).2011 Jul;216(1):63-73. doi: 10.1007/s00213-011-2192-9. Epub 2011 Feb 11.PubMed PMID:  21312031.