MedKooCat#:205829
Name:CC-115
CAS#:1228013-15-7(freebase)
ChemicalFormula:C16H16N8O
ExactMass:336.14471
MolecularWeight:336.14
ElementalAnalysis:C,57.13;H,4.79;N,33.31;O,4.76
RelatedCAS#:1228013-15-7(freebase) 1300118-55-1(HCl)
Synonym:CC115;CC-115;CC115.
IUPAC/ChemicalName:1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one
InChiKey:GMYLVKUGJMYTFB-UHFFFAOYSA-N
InChiCode:InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)
SMILESCode:O=C1CNC2=NC=C(C3=CC=C(C4=NC=NN4)N=C3C)N=C2N1CC
RelatedCAS#
CAS#1228013-15-7(CC-115freebase);
CAS#1300118-55-1(CC-115.xHClsalt)
1:ThijssenR,TerBurgJ,GarrickB,vanBochoveGG,BrownJR,FernandesSM,RodríguezMS,MichotJM,HallekM,EichhorstB,ReinhardtHC,BendellJ,DerksIA,vanKampenRJ,HegeK,KerstenMJ,TroweT,FilvaroffEH,ElderingE,KaterAP.DualTORK/DNA-PKinhibitionblockscriticalsignalingpathwaysinchroniclymphocyticleukemia.Blood.2016Jul28;128(4):574-83.doi:10.1182/blood-2016-02-700328.Epub2016May27.PubMedPMID:27235137.
2:MortensenDS,Perrin-NinkovicSM,ShevlinG,ElsnerJ,ZhaoJ,WhitefieldB,TehraniL,SapienzaJ,RiggsJR,ParnesJS,PapaP,PackardG,LeeBG,HarrisR,CorreaM,BahmanyarS,RichardsonSJ,PengSX,LeistenJ,KhambattaG,HickmanM,GamezJC,BisonetteRR,ApuyJ,CathersBE,CananSS,MoghaddamMF,RaymonHK,WorlandP,NarlaRK,FultzKE,SankarS.OptimizationofaSeriesofTriazoleContainingMammalianTargetofRapamycin(mTOR)KinaseInhibitorsandtheDiscoveryofCC-115.JMedChem.2015Jul23;58(14):5599-608.doi:10.1021/acs.jmedchem.5b00627.Epub2015Jul8.PubMedPMID:26102506.
3:SaizC,WipfP,MantaE,MahlerG.ReversIBLethiazolidineexchange:anewreactionsuitablefordynamiccombinatorialchemistry.OrgLett.2009Aug6;11(15):3170-3.doi:10.1021/ol901104a.Erratumin:OrgLett.2010Jul16;12(14):3284.PubMedPMID:19585999;PubMedCentralPMCID:PMC2736333.
4:WarheitDB,HartskyMA,McHughTA,KellarKA.Biopersistenceofinhaledorganicandinorganicfibersinthelungsofrats.EnvironHealthPerspect.1994Oct;102Suppl5:151-7.PubMedPMID:7882921;PubMedCentralPMCID:PMC1567301.