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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/CKD-516 HCl/1/205833
产品编号:205833
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
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美  元  价:待定
品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
公司分类:
MedKoo/CKD-516 HCl/1/205833
商品介绍

CKD-516 HCl

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:205833

CAS#:1240321-53-2 ( HCl salt)

Description:CKD-516 is tubulin inhibitor for solid cancer, which was initiated phase 1 trial in Korea in 2010. CKD-516 selectively disrupted tubulin component of the endothelial cytoskeleton. Serial DCE-MRI showed a significant decrease in K-trans and IAUGC parameters from baseline at 4 h (39.9 % in K-trans; -45.0 % in IAUGC) and at 24 h (-32.2 % in K-trans; -36.5 % in IAUGC), and a significant recovery at 48 h (22.9 % in K-trans; 34.8 % in IAUGC) following administration of CKD-516 at a 0.7-mg/kg dose. When the tumors were stratified according to the initial K-trans value of 0.1, tumors with a high K-trans > 0.1 which was indicative of having well-developed pre-existing vessels, showed greater reduction in K-trans and IAUGC values.

Price and Availability

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Pricing updated 2021-01-23.Prices are subject to change without notice.

CKD-516 HClis not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205833Name: CKD-516 HClCAS#: 1240321-53-2 ( HCl salt)Chemical Formula: C26H29ClN6O5SExact Mass: Molecular Weight: 573.06Elemental Analysis: C, 54.49; H, 5.10; Cl, 6.19; N, 14.67; O, 13.96; S, 5.60

Synonym:CKD516; CKD-516; CKD 516; CKD 516 HCl.

IUPAC/Chemical Name:(S)-N-(4-(3-(1H-1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl)thiazol-2-yl)-2-amino-3-methylbutanamide hydrochloride

InChi Key:FIAUXCMEQTWLQZ-FTBISJDPSA-N

InChi Code:InChI=1S/C26H28N6O5S.ClH/c1-14(2)22(27)25(34)31-26-30-18(11-38-26)15-6-7-17(19(8-15)32-13-28-12-29-32)23(33)16-9-20(35-3)24(37-5)21(10-16)36-4;/h6-14,22H,27H2,1-5H3,(H,30,31,34);1H/t22-;/m0./s1

SMILES Code:CC(C)[C@H](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O.[H]Cl

Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

  Related: 1240321-53-2 (CKD-516 HCl salt) 1188371-47-2 (CKD-516 free base).  

References

1: Kim KW, Lee JM, Jeon YS, Lee IJ, Choi Y, Park J,Kiefer B, Kim C, Han JK, Choi BI. Vascular disrupting effect of CKD-516:preclinical study using DCE-MRI. Invest New Drugs. 2013Oct;31(5):1097-106. doi: 10.1007/s10637-012-9915-6. Epub 2013 Jan 9.Erratum in: Invest New Drugs. 2013 Oct;31(5):1397. PubMed PMID:23299389.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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