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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/DAT-230/1/406507
产品编号:406507
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
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品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
公司分类:
MedKoo/DAT-230/1/406507
商品介绍

DAT-230

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406507

CAS#:1504583-00-9

Description:DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria.

Price and Availability

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Pricing updated 2021-01-23.Prices are subject to change without notice.

DAT-230 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406507Name: DAT-230CAS#: 1504583-00-9Chemical Formula: C20H21NO2SExact Mass: 339.1293Molecular Weight: 339.45Elemental Analysis: C, 70.77; H, 6.24; N, 4.13; O, 9.43; S, 9.45

Synonym:DAT230; DAT 230; DAT-230.

IUPAC/Chemical Name:2-methoxy-5-(2-(3-methoxy-4,5-dimethylphenyl)thiophen-3-yl)aniline

InChi Key:NPXKFXXMFDKVTM-UHFFFAOYSA-N

InChi Code:InChI=1S/C20H21NO2S/c1-12-9-15(11-19(23-4)13(12)2)20-16(7-8-24-20)14-5-6-18(22-3)17(21)10-14/h5-11H,21H2,1-4H3

SMILES Code:NC1=CC(C2=C(C3=CC(C)=C(C)C(OC)=C3)SC=C2)=CC=C1OC

Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Qiao F, Zuo D, Wang H, Li Z, Qi H, Zhang W, Wu Y.DAT-230, a Novel Microtubule Inhibitor, Induced Aberrant Mitosis and Apoptosis in SGC-7901 Cells.Biol Pharm Bull. 2013;36(2):193-201. PubMed PMID: 23370351.

2: Qiao F, Zuo D, Shen X, Qi H, Wang H, Zhang W, Wu Y. DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducingG2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080.Cancer Chemother Pharmacol. 2012 Aug;70(2):259-70. doi:10.1007/s00280-012-1907-x. Epub2012 Jun 30. PubMed PMID: 22752214.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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