GSK1059615

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WARNING: This product is for research use only, not for human or veterinary use.

Description:GSK1059615 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax is a member of the proapoptotic Bcl-2 family of proteins. PIK3, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Price and Availability

GSK1059615, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 205739Name: GSK1059615CAS#: 958852-01-1Chemical Formula: C18H11N3O2SExact Mass: 333.0572Molecular Weight: 333.36384Elemental Analysis:C, 64.85; H, 3.33; N, 12.60; O, 9.60; S, 9.62

Synonym:GSK1059615; GSK-1059615; GSK-1059615.

IUPAC/Chemical Name:(E)-4-((4-(pyridin-4-yl)quinolin-6-yl)methylene)thiazolidine-2,5-dione

InChi Key:SSROGLWTGKZPRA-MHWRWJLKSA-N

InChi Code:InChI=1S/C18H11N3O2S/c22-17-16(21-18(23)24-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,23)/b16-10+

SMILES Code:O=C(N/C1=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2)SC1=O

Technical Data

Additional Information

References