IG-105

WARNING: This product is for research use only, not for human or veterinary use.

Description:IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC(50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein substrate. It inhibited microtubule assembly followed by M-phase arrest, Bcl-2 inactivation, and then apoptosis through caspase pathways.

Price and Availability

IG105 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406510Name: IG-105CAS#: 905978-63-4Chemical Formula: C20H19N3O4SExact Mass: 397.10963Molecular Weight: 397.45Elemental Analysis: C, 60.44; H, 4.82; N, 10.57; O, 16.10; S, 8.07

Synonym:IG105; IG-105; IG 105.

IUPAC/Chemical Name:N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide.

InChi Key:JTPDYODKXJLRLA-UHFFFAOYSA-N

InChi Code:InChI=1S/C20H19N3O4S/c1-23-17-7-5-4-6-14(17)15-12-13(8-10-18(15)23)28(24,25)22-16-9-11-19(26-2)21-20(16)27-3/h4-12,22H,1-3H3

SMILES Code:O=S(C1=CC2=C(C=C1)N(C)C3=C2C=CC=C3)(NC4=CC=C(OC)N=C4OC)=O

Technical Data

Additional Information

References

1: Li J, Si Y, Hu J, Liu L, Deng Y, He J, Zhang NM,Zhou D. Enhancing medical compliance of patients with convulsive epilepsy in rural community: arandomizedintervention trial. Epilepsia. 2013 Nov;54(11):1988-96. doi:10.1111/epi.12382. Epub 2013 Sep 30. PubMed PMID: 24117425.

2: Wang YM, Hu LX, Liu ZM, You XF, Zhang SH, Qu JR, Li ZR, Li Y, KongWJ, He HW,Shao RG, Zhang LR, Peng ZG, Boykin DW, Jiang JD. N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as anovel tubulin ligand against human cancer. Clin Cancer Res. 2008 Oct 1;14(19):6218-27.doi: 10.1158/1078-0432.CCR-08-0550. PubMed PMID: 18829501.