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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/G-573featured/250mg/406200
产品编号:406200
市  场 价:¥4600.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$230.00
品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
公司分类:
MedKoo/G-573featured/250mg/406200
商品介绍

G-573
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406200

CAS#:22868-35-5

Description:G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406  µM. The IC(50) values for tumour growth inhibition in HCT116 and H2122 were estimated to be 3.43 and 2.56 µM, respectively. ED(50) estimates in HCT116 and H2122 mouse xenograft models were estimated to be ~4.6 and 1.9 mg/kg/day, respectively.

Price and Availability

SizePriceShipping out timeQuantity
250mgUSD 2302 Weeks
1gUSD 4902 Weeks
5gUSD 14002 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

G-573, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406200Name: G-573CAS#: 22868-35-5Chemical Formula: C13H9ClN2Exact Mass: 228.04543Molecular Weight: 228.68Elemental Analysis: C, 68.28; H, 3.97; Cl, 15.50; N, 12.25

Synonym:G573; G-573; G 573.

IUPAC/Chemical Name:2-(3-chlorophenyl)-1H-benzo[d]imidazole

InChi Key:BGYHTIIVIGGCIF-UHFFFAOYSA-N

InChi Code:InChI=1S/C13H9ClN2/c14-10-5-3-4-9(8-10)13-15-11-6-1-2-7-12(11)16-13/h1-8H,(H,15,16)

SMILES Code:ClC1=CC(C2=NC3=CC=CC=C3N2)=CC=C1

Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Hatzivassiliou G, Haling JR, Chen H, Song K, PriceS, Heald R, Hewitt JF, Zak  M, Peck A, Orr C, Merchant M, HoeflichKP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M,Friedman LS, Malek S, Belvin M. Mechanism of MEK inhibition determinesefficacy in mutant KRAS- versus BRAF-driven cancers. Nature. 2013 Sep12;501(7466):232-6. doi: 10.1038/nature12441. Epub 2013 Aug 11. Erratum in: Nature. 2013 Oct 10;502(7470):258. PubMed PMID: 23934108.

2: Choo EF, Belvin M, Chan J, Hoeflich K, Orr C, Robarge K, Yang X, ZakM, Boggs  J. Preclinical disposition and pharmacokinetics-pharmacodynamicmodeling of biomarker response and tumour growth inhibition in xenograftmouse models of G-573, a MEK inhibitor. Xenobiotica. 2010Nov;40(11):751-62. doi: 10.3109/00498254.2010.514365. PubMed PMID:20836753.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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