AS-605240

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WARNING: This product is for research use only, not for human or veterinary use.

Description:AS605240 is a selective PI3Kgamma inhibitor, has been proved effective on several inflammatory diseases. Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis.

Price and Availability

AS-605240, purity > 98%,is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 200296Name: AS-605240CAS#: 648450-29-7Chemical Formula: C12H7N3O2SExact Mass: 257.0259Molecular Weight: 257.27Elemental Analysis:C, 56.02; H, 2.74; N, 16.33; O, 12.44; S, 12.46

Synonym:AS 605240; AS605240; AS-605240.

IUPAC/Chemical Name:(E)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione

InChi Key:SQWZFLMPDUSYGV-UXBLZVDNSA-N

InChi Code:InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6+

SMILES Code:O=C(NC/1=O)SC1=CC2=CC=C3N=CC=NC3=C2

Technical Data

References

1: Azzi J, Moore RF, Elyaman W, Mounayar M, El HaddadN, Yang S, Jurewicz M, Takakura A, Petrelli A, Fiorina P, Ruckle T, Abdi R. The noveltherapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmunediabetes. Diabetes. 2012 Jun;61(6):1509-18. doi: 10.2337/db11-0134. Epub 2012 Mar8. PubMed PMID: 22403300; PubMed Central PMCID: PMC3357271.

2: Song LF, Jiang W, Qing Y, Hu XH, Li Y, Tong QY, Wu XH. [Theantagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy andcardiac fibrosis induced by isoproterenol in rats]. Sichuan Da Xue Xue Bao YiXue Ban. 2011 Jul;42(4):471-4. Chinese. PubMed PMID: 21866628.

3: Wei X, Han J, Chen ZZ, Qi BW, Wang GC, Ma YH, Zheng H, Luo YF, WeiYQ, Chen LJ. A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats. Biochem Biophys Res Commun.2010 Jun 25;397(2):311-7. doi: 10.1016/j.bbrc.2010.05.109. Epub 2010 May 26.PubMed PMID: 20510675.

4: Jin K, Song LF, He CM, Wang ZL, Hu XH, Wu XH. [Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice]. SichuanDa Xue Xue Bao Yi Xue Ban. 2009 Sep;40(5):817-20, 825. Chinese. PubMed PMID:19950590.