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MedKoo/Dilmapimodfeatured/10mg/205999

  • 产品编号: 205999
  • 美  元  价: $80.00
  • 市  场  价: ¥1600.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: MedKoo Biosciences, Inc
  • 产品分类:
  • 公司分类: Apoptosis
MedKoo/Dilmapimodfeatured/10mg/205999
  • MedKoo/Dilmapimodfeatured/10mg/205999
商品介绍

Dilmapimod
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:205999

CAS#:444606-18-2 (free base)

Description:Dilmapimod, also known as SB-681323 and GW-681323 , is p38 MAPK inhibitor. SB-681323 inhibited the p38 MAPK pathway to a greater degree than prednisolone did. SB-681323 inhibited TNF-alpha production. SB-681323 is a potent p38 MAPK inhibitor that potentially suppresses inflammation in COPD. The treatment with SB-681832 is a safe and effective means of reducing hsCRP in patients undergoing elective PCI.

Price and Availability

SizePriceShipping out timeQuantity
10mgUSD 80Same day
25mgUSD 150Same day
50mgUSD 250Same day
100mgUSD 450Same day
200mgUSD 850Same day
500mgUSD 1850Same day
1gUSD 29502 Weeks
2gUSD 54502 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

Dilmapimod, purity > 98%, is in stock.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205999Name: DilmapimodCAS#: 444606-18-2 (free base)Chemical Formula: C23H19F3N4O3Exact Mass: 456.14093Molecular Weight: 456.42Elemental Analysis: C, 60.52; H, 4.20; F, 12.49; N, 12.28; O, 10.52

Related CAS #:937169-00-1 (tosylate)444606-18-2 (free base)

Synonym:SB681323; SB 681323; SB-681323; GW 681323; GW-681323; GW681323; Dilmapimod.

IUPAC/Chemical Name:8-(2,6-difluorophenyl)-2-((1,3-dihydroxypropan-2-yl)amino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key:ORVNHOYNEHYKJG-UHFFFAOYSA-N

InChi Code:InChI=1S/C23H19F3N4O3/c1-12-9-13(24)5-6-15(12)20-16-7-8-19(33)30(21-17(25)3-2-4-18(21)26)22(16)29-23(28-20)27-14(10-31)11-32/h2-9,14,31-32H,10-11H2,1H3,(H,27,28,29)

SMILES Code:O=C1C=CC2=C(C3=CC=C(F)C=C3C)N=C(NC(CO)CO)N=C2N1C4=C(F)C=CC=C4F

Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:
View CoA: current batch, Lot#T20D03P06

QC Data:
View QC data: current batch, Lot#T20D03P06

Safety Data Sheet (SDS):
View Safety Data Sheet (SDS)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Betts JC, Mayer RJ, Tal-Singer R, Warnock L,Clayton C, Bates S, Hoffman BE, Larminie C, Singh D. Gene expressionchanges caused by the p38 MAPK inhibitor dilmapimod in COPD patients:analysis of blood and sputum samples from a randomized,placebo-controlled clinical trial. Pharmacol Res Perspect. 2015Feb;3(1):e00094. doi: 10.1002/prp2.94. Epub 2014 Dec 9. PubMed PMID:25692013; PubMed Central PMCID: PMC4317226.

品牌介绍


MedKoo是世界领先的供应商之一的抗癌化学试剂和激酶抑制剂。我们制造、销售和分发高质量的抗癌小分子肿瘤学研究试剂。我们的使命是建立世界上最全面的抗癌小分子的集合。我们也为医药行业提供高质量的研究服务、医学研究机构和学术机构。我们致力于提供优质的服务。

MedKoo是世界领先的供应商之一的抗癌化学试剂和激酶抑制剂。我们制造、销售和分发高质量的抗癌小分子肿瘤学研究试剂。我们的使命是建立世界上最全面的抗癌小分子的集合。我们也为医药行业提供高质量的研究服务、医学研究机构和学术机构。我们致力于提供优质的服务和分子有竞争力的价格。MedKoo是您可靠的合作伙伴采购药物发现和药物分子。




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MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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