Synonym:KX1004;KX1004;KX1-004.

IUPAC/ChemicalName:5-fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxamide.

InChiKey:TUIHIKXCMCXXJG-UHFFFAOYSA-N

InChiCode:InChI=1S/C16H13FN2O2/c17-12-4-5-14-11(7-12)8-15(19-14)16(21)18-9-10-2-1-3-13(20)6-10/h1-8,19-20H,9H2,(H,18,21)

SMILESCode:O=C(C(N1)=CC2=C1C=CC(F)=C2)NCC3=CC=CC(O)=C3

TechnicalData

AdditionalInformation

References

1:FetoniAR,BielefeldEC,PaludettiG,NicoteraT,HendersonD.Aputativeroleofp53pathwayagainstimpulsenoiseinduceddamageasdemonstratedbyprotectionwithpifithrin-alphaandaSrcinhibitor.NeurosciRes.2014Apr-May;81-82:30-7.doi:10.1016/j.neures.2014.01.006.Epub2014Jan25.PubMedPMID:24472721.

2:BielefeldEC,TanakaC,ChenGD,ColingD,LiM,HendersonD,FetoniAR.AnSrc-proteintyrosinekinaseinhibitortoreducecisplatinototoxicitywhilepreservingitsantitumoreffect.AnticancerDrugs.2013Jan;24(1):43-51.doi:10.1097/CAD.0b013e32835739fd.PubMedPMID:22828384.

3:BielefeldEC,HangauerD,HendersonD.Protectionfromimpulsenoise-inducedhearinglosswithnovelSrc-proteintyrosinekinaseinhibitors.NeurosciRes.2011Dec;71(4):348-54.doi:10.1016/j.neures.2011.07.1836.Epub2011Aug5.PubMedPMID:21840347;PubMedCentralPMCID:PMC3210387.

4:BielefeldEC,WantuckR,HendersonD.PostexposuretreatmentwithaSrc-PTKinhibitorincombinationwithN-l-acetylcysteinetoreducenoise-inducedhearingloss.NoiseHealth.2011Jul-Aug;13(53):292-8.doi:10.4103/1463-1741.82962.PubMedPMID:21768733.

5:BielefeldEC,HynesS,PryznoschD,LiuJ,ColemanJK,HendersonD.AcomparisonoftheprotectiveeffectsofsystemicadmiNISTrationofapro-glutathionedrugandaSrc-PTKinhibitoragainstnoise-inducedhearingloss.NoiseHealth.2005Oct-Dec;7(29):24-30.PubMedPMID:17478966.

6:HarrisKC,HuB,HangauerD,HendersonD.Preventionofnoise-inducedhearinglosswithSrc-PTKinhibitors.HearRes.2005Oct;208(1-2):14-25.Epub2005Jun13.PubMedPMID:15950415.