AZ3146

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WARNING: This product is for research use only, not for human or veterinary use.

Description:AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.

Price and Availability

AZ3146, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406239Name: AZ3146CAS#: 1124329-14-1Chemical Formula: C24H32N6O3Exact Mass: 452.25359Molecular Weight: 452.55Elemental Analysis: C, 63.70; H, 7.13; N, 18.57; O, 10.61

Synonym:AZ3146; AZ 3146; AZ-3146

IUPAC/Chemical Name:9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one

InChi Key:YUKWVHPTFRQHMF-UHFFFAOYSA-N

InChi Code:InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)

SMILES Code:O=C1N(C)C2=CN=C(NC3=CC=C(OC4CCN(C)CC4)C=C3OC)N=C2N1C5CCCC5

Technical Data

Additional Information

References

1: Hewitt L, Tighe A, Santaguida S, White AM, JonesCD, Musacchio A, Green S, Taylor SS. Sustained Mps1 activity is requiredin mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J CellBiol. 2010 Jul 12;190(1):25-34. doi: 10.1083/jcb.201002133. PubMed PMID:20624899; PubMed Central PMCID: PMC2911659.