Synonym:CEP11981;CEP11981;CEP11981

IUPAC/ChemicalName:13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-4,7,8,13-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6(2H)-one

InChiKey:AEULIVPVIDOLIN-UHFFFAOYSA-N

InChiCode:InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)

SMILESCode:O=C1NCC2=C1C(C3=CN(C)N=C3CC4)=C4C(N5CC(C)C)=C2C6=C5C=CC(NC7=NC=CC=N7)=C6

TechnicalData

AdditionalInformation

References

1:HudkinsRL,BecknellNC,ZulliAL,UnderinerTL,AngelesTS,AimoneLD,Albom MS,ChangH,MiknyoczkiSJ,HunterK,Jones-BolinS,ZhaoH,BaconER,MallamoJP,AtorMA,RuggeriBA.SynthesisandBIOLOGicalprofileofthepan-vascularendothelialgrowthfactorreceptor/tyrosinekinasewithimmunoglobulinandepidermalgrowthfactor-likehomologydomains2(VEGF-R/TIE-2)inhibitor11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one(CEP-11981):anoveloncologytherapeuticagent.JMedChem.2012Jan26;55(2):903-13.doi:10.1021/jm201449n.Epub2012Jan6.Erratumin:JMedChem.2012Apr26;55(8):4025.PubMedPMID:22148921.