Y11

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WARNING: This product is for research use only, not for human or veterinary use.

Description:Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.

Price and Availability

Y11, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406462Name: Y11CAS#: 1086639-59-9Chemical Formula: C8H17BrN4OExact Mass: 264.05857Molecular Weight: 265.15078Elemental Analysis: C, 36.24; H, 6.46; Br, 30.14; N, 21.13; O, 6.03

Synonym:Y11; Y-11; Y 11

IUPAC/Chemical Name:(3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide

InChi Key:HBPXFHNNLMCUPA-UHFFFAOYSA-M

InChi Code:InChI=1S/C8H17N4O.BrH/c13-2-1-12-6-9-3-10(7-12)5-11(4-9)8-12;/h13H,1-8H2;1H/q+1;/p-1

SMILES Code:OCC[N+]12C[N@]3C[N@](C2)C[N@](C3)C1.[Br-]

Technical Data

Additional Information

References

 1. McLaughlin, Mark; Hazlehurst, Lori; Jain,Priyesh; Emmons, Michael F.; Gebhard, Anthony W.; Nair, Rajesh R.Preparation of peptides as integrin interaction inhibitors for thetreatment of cancer.  PCT Int. Appl. (2013), WO 2013170066 A120131114.