Derazantinib

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WARNING: This product is for research use only, not for human or veterinary use.

Description:Derazantinib, also known as ARQ-087, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.

Price and Availability

Derazantinib, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 205946Name: DerazantinibCAS#: 1234356-69-4Chemical Formula: C29H29FN4O Exact Mass: 468.2325Molecular Weight: 468.5764Elemental Analysis: C, 74.34; H, 6.24; F, 4.05; N, 11.96; O, 3.41

Synonym:ARQ 087; ARQ087; ARQ-087; Derazantinib

IUPAC/Chemical Name:(6R)-6-(2-fluorophenyl)-N-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

InChi Key:KPJDVVCDVBFRMU-AREMUKBSSA-N

InChi Code:InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1

SMILES Code:COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1

Technical Data

Additional Information

References

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