Pemigatinib HCl

WARNING: This product is for research use only, not for human or veterinary use.

Description:Pemigatinib, also known as INCB054828, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. FGFR inhibitor INCB054828 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells.

Price and Availability

Pemigatinib HClis not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 206195Name: Pemigatinib HClCAS#: 1513857-77-6 (HCl)Chemical Formula: C24H28ClF2N5O4 Exact Mass: 523.1798Molecular Weight: 523.9658Elemental Analysis: C, 55.02; H, 5.39; Cl, 6.77; F, 7.25; N, 13.37; O, 12.21

Related CAS #:1513857-77-6 (free base)1513857-77-6 (HCl)

Synonym:INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828. Pemigatinib HCl; Pemigatinib hydrochloride

IUPAC/Chemical Name:3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(morpholin-4-yl)methyl]-1,3,4,7-tetrahydro-2Hpyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one hydrochloride

InChi Key:JAUWPXUYFRLMAN-UHFFFAOYSA-N

InChi Code:InChI=1S/C24H27F2N5O4.ClH/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26;/h9-11H,4-8,12-13H2,1-3H3,(H,27,28);1H

SMILES Code:O=C1N(CC)C2=C3C(NC(CN4CCOCC4)=C3)=NC=C2CN1C5=C(F)C(OC)=CC(OC)=C5F.[H]Cl

Technical Data

Additional Information

References