Peficitinib free base

WARNING: This product is for research use only, not for human or veterinary use.

Description:Peficitinib, also known as ASP015K and JNJ-54781532, is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. ASP015K inhibited JAK1, JAK2, JAK3 and TYK2 enzyme activities with IC50 values of 3.9, 5.0, 0.71 and 4.8 nM, respectively. ASP015K inhibited the IL-2-induced proliferation of human T cells with an IC50value of 18 nM. Moreover, ASP015K was 14-fold more potent against JAK1/3 than JAK2/2 on the basis of EPO-induced proliferation of human leukemia cells.

Price and Availability

Peficitinib, purity > 98%, is out of stock. We will list price when it in stock.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 206125Name: Peficitinib free baseCAS#: 944118-01-8 (free base)Chemical Formula: C18H22N4O2Exact Mass: 326.17428Molecular Weight: 326.39Elemental Analysis: C, 66.24; H, 6.79; N, 17.17; O, 9.80

Related CAS #:1353219-05-2 (HBr)944118-01-8 (free base)

Synonym:Peficitinib; ASP015K; ASP015K; ASP 015K; JNJ54781532; JNJ54781532; JNJ 54781532.

IUPAC/Chemical Name:4-(((1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

InChi Key:DREIJXJRTLTGJC-KDJQDEFKSA-N

InChi Code:InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9-,10-,11+,14+,18-

SMILES Code:O=C(C1=CN=C(NC=C2)C2=C1N[C@H]3[C@]4([H])C[C@@]5([H])C[C@](C4)(O)C[C@]3([H])C5)N

Technical Data

Additional Information

References