Motesanib

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WARNING: This product is for research use only, not for human or veterinary use.

Description:Motesanib, also known as AMG-706, is the orally bioavailable multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

Price and Availability

Motesanib (free base), purity > 98%, is in stock. The same day shipping after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 201934Name: MotesanibCAS#: 453562-69-1 (free base)Chemical Formula: C22H23N5OExact Mass: 373.1902Molecular Weight: 373.46Elemental Analysis: C, 70.76; H, 6.21; N, 18.75; O, 4.28

Related CAS #:453562-69-1 (free base)857876-30-3 (phosphate)

Synonym:AMG 706; AMG706; AMG706; motesanib free base

IUPAC/Chemical Name:N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4- ylmethyl)amino]pyridine-3-carboxamide

InChi Key:RAHBGWKEPAQNFF-UHFFFAOYSA-N

InChi Code:InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)

SMILES Code:O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC4=C(C=C3)C(C)(C)CN4

Technical Data

Additional Information

Motesanib is an orally-administered small molecule antagonist of vascular endothelial growth factor receptors 1, 2 and 3 (“VEGFR1-3”), platelet-derived growth factor receptor (“PDGFR”) and stem cell factor receptor (“c-kit”). It is being investigated as a cancer treatment. We are developing this product in collaboration with Takeda.      

References

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