AZM-475271

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WARNING: This product is for research use only, not for human or veterinary use.

Description:AZM475271 is orally Src tyrosine kinase inhibitor with potential anticancer and antimetastatic activities. Chemical structurally, AZM-475271 is the 4-amino-quinazoline based anticancer agent. AZM475271 remarkably inhibits growth and metastasis of orthotopically implanted human pancreatic carcinoma cells in nude mice. AZM475271 suppresses tumor growth and metastasis in vitro and in vivo potentially by anti-angiogenic mechanisms.

Price and Availability

AZM-475271, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 200315Name: AZM-475271CAS#: 476159-98-5Chemical Formula: C23H27ClN4O3Exact Mass: 442.17717Molecular Weight: 442.94Elemental Analysis:C, 62.37; H, 6.14; Cl, 8.00; N, 12.65; O, 10.84

Synonym:AZM475271; AZM-475271; AZM 475271.

IUPAC/Chemical Name:N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

InChi Key:WPOXAFXHRJYEIC-UHFFFAOYSA-N

InChi Code:InChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27)

SMILES Code:CN1CCC(COC2=CC3=NC=NC(NC4=CC(OC)=CC=C4Cl)=C3C=C2OC)CC1

Technical Data

Additional Information

Treatment with AZM475271 alone reduced the primary pancreatic tumor volume by approximately 40%, whereas AZM475271 plus gemcitabine reduced tumor volume by 90%. Furthermore, treatment with AZM475271 and gemcitabine significantly reduced metastasis: none of eight animals who received the combination treatment had lymph node or liver metastases, compared with five of five and three of five animals, respectively, in the control group (P = 0.001). Src inhibition by AZM475271 (alone or with gemcitabine) was associated with significantly reduced tumor cell proliferation, decreased tumor microvessel density, and increased apoptosis in vivo. Moreover, these effects were all significantly increased when gemcitabine was combined with AZM475271 compared with gemcitabine alone. CONCLUSIONS: Src inhibition by AZM475271, either alone or in combination with gemcitabine, demonstrated significant antitumor and antimetastatic activity in an orthotopic nude mouse model for human pancreatic cancer. The combination of AZM475271 with gemcitabine sensitized tumor cells to the cytotoxic effect of gemcitabine. [ source: Clin Cancer Res. 2004 Dec 1;10(23):8028-36. ]  

References

 1: Ischenko I, Seeliger H, Camaj P, KleespiesA, Guba M, Eichhorn ME, Jauch KW, Bruns CJ. Src tyrosine kinaseinhibition suppresses lymphangiogenesis in vitro and in vivo. CurrCancer Drug Targets. 2010 Aug;10(5):546-53. PubMed PMID: 20370688.

2: Ischenko I, Guba M, Yezhelyev M, Papyan A, Schmid G, Green T, FennellM, Jauch KW, Bruns CJ. Effect of Src kinase inhibition on metastasis andtumor angiogenesis in human pancreatic cancer. Angiogenesis.2007;10(3):167-82. Epub 2007 May 8. PubMed PMID: 17486419.

3: Yezhelyev MV, Koehl G, Guba M, Brabletz T, Jauch KW, Ryan A, Barge A,Green T, Fennell M, Bruns CJ. Inhibition of SRC tyrosine kinase astreatment for human pancreatic cancer growing orthotopically in nudemice. Clin Cancer Res. 2004 Dec 1;10(23):8028-36. PubMed PMID: 15585638.