GSK143

WARNING: This product is for research use only, not for human or veterinary use.

Description:GSK143 is a potent and highly selective SYK inhibitor showing good efficacy in the rat Arthus model. The Syk inhibitor GSK143 reduces macrophage activation and mast cell degranulation in vitro. In addition, it inhibits manipulation-induced intestinal muscular inflammation and restores intestinal transit in mice.

Price and Availability

GSK143 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406269Name: GSK143CAS#: 1240390-27-5Chemical Formula: C17H22N6O2Exact Mass: 342.18042Molecular Weight: 342.39558Elemental Analysis: C, 59.63; H, 6.48; N, 24.54; O, 9.35

Synonym:GSK143; GSK 143; GSK-143.

IUPAC/Chemical Name:2-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)-4-(p-tolylamino)pyrimidine-5-carboxamide

InChi Key:KBPYMFSSFLOJPH-UONOGXRCSA-N

InChi Code:InChI=1S/C17H22N6O2/c1-10-2-4-11(5-3-10)21-16-12(15(19)24)8-20-17(23-16)22-14-6-7-25-9-13(14)18/h2-5,8,13-14H,6-7,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23)/t13-,14+/m0/s1

SMILES Code:O=C(C1=CN=C(N[C@H]2[C@@H](N)COCC2)N=C1NC3=CC=C(C)C=C3)N

Technical Data

Additional Information

References

1: van Bree SH, Gomez-Pinilla PJ, van de BovenkampFS, Di Giovangiulio M, Farro G, Nemethova A, Cailotto C, de Jonge WJ, Lee K, Ramirez-Molina C, LugoD, Skynner MJ, Boeckxstaens GE, Matteoli G. Inhibition of spleen tyrosine kinase as treatment of postoperative ileus. Gut. 2012 Dec 13. [Epub ahead ofprint] PubMedPMID: 23242119.

2: Liddle J, Atkinson FL, Barker MD, Carter PS, Curtis NR, Davis RP,Douault C, Dickson MC, Elwes D, Garton NS, Gray M, Hayhow TG, Hobbs CI, Jones E,Leach S, Leavens K, Lewis HD, McCleary S, Neu M, Patel VK, Preston AG,Ramirez-Molina C, Shipley TJ, Skone PA, Smithers N, Somers DO, Walker AL, Watson RJ,Weingarten GG. Discovery of GSK143, a highly potent, selective and orally efficaciousspleen tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2011 Oct15;21(20):6188-94. doi: 10.1016/j.bmcl.2011.07.082. Epub 2011 Aug 12. PubMed PMID: 21903390.