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主营:抗癌化学试剂和激酶抑制剂
℡ 4000-520-616
℡ 4000-520-616
MedKoo/Tamatinib free basefeatured/10mg/205926
产品编号:205926
市  场 价:¥3000.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
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电话号码:4000-520-616
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美  元  价:$150.00
品      牌: MedKoo
公      司:MedKoo Biosciences, Inc
公司分类:
MedKoo/Tamatinib free basefeatured/10mg/205926
商品介绍

Tamatinib free base
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:205926

CAS#:841290-80-0 (free base)

Description:Tamatinib, also known as R406, is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling (EC(50) for degranulation = 56-64 nM). The primary target for R406 is the spleen tyrosine kinase (Syk). R406 inhibited phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells. R406 bound to the ATP binding pocket of Syk and inhibited its kinase activity as an ATP-competitive inhibitor (K(i) = 30 nM).

Price and Availability

SizePriceShipping out timeQuantity
10mgUSD 150Same day
25mgUSD 250Same day
50mgUSD 450Same day
100mgUSD 750Same day
200mgUSD 1250Same day
500mgUSD 1950Same day
1gUSD 2950Same day
2gUSD 5450Same day
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

Tamatinib free base, purity > 98%, is in stock. The same day shipping after order is received.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 205926Name: Tamatinib free baseCAS#: 841290-80-0 (free base)Chemical Formula: C22H23FN6O5Exact Mass: 470.1714Molecular Weight: 470.45Elemental Analysis: C, 56.17; H, 4.93; F, 4.04; N, 17.86; O, 17.00

Related CAS #:841290-81-1 (besylate)841290-80-0 (free base)

Synonym:R 406, R406, R406, Tamatinib

IUPAC/Chemical Name:6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

InChi Key:NHHQJBCNYHBUSI-UHFFFAOYSA-N

InChi Code:InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)

SMILES Code:O=C1NC2=NC(NC3=NC(NC4=CC(OC)=C(OC)C(OC)=C4)=NC=C3F)=CC=C2OC1(C)C

Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:
View CoA: current batch, Lot#C20R11B18

QC Data:
View QC data: current batch, Lot#C20R11B18

Safety Data Sheet (SDS):
View Safety Data Sheet (SDS)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not soluble in water.

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

References

1: Lhermusier T, van Rottem J, Garcia C, Xuereb JM,Ragab A, Martin V, Gratacap MP, Sié P, Payrastre B. The Syk-kinaseinhibitor R406 impairs platelet activation and monocyte tissue factorexpression triggered by heparin-PF4 complex directed antibodies. JThromb Haemost. 2011 Oct;9(10):2067-76. doi:10.1111/j.1538-7836.2011.04470.x. PubMed PMID: 21848694.

2: Sweeny DJ, Li W, Grossbard E, Lau DT. Contribution of gut bacteria tothe metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 incynomolgus monkey. Xenobiotica. 2010 Jun;40(6):415-23. doi:10.3109/00498251003734244. PubMed PMID: 20415544.

3: Sweeny DJ, Li W, Clough J, Bhamidipati S, Singh R, Park G, Baluom M,Grossbard E, Lau DT. Metabolism of fostamatinib, the oral methylenephosphate prodrug of the spleen tyrosine kinase inhibitor R406 inhumans: contribution of hepatic and gut bacterial processes to theoverall biotransformation. Drug Metab Dispos. 2010 Jul;38(7):1166-76.doi: 10.1124/dmd.110.032151. Epub 2010 Apr 6. PubMed PMID: 20371637.

4: Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, WierdaWG, Gandhi V, Burger JA. B-cell antigen receptor signaling enhanceschronic lymphocytic leukemia cell migration and survival: specifictargeting with a novel spleen tyrosine kinase inhibitor, R406. Blood.2009 Jul 30;114(5):1029-37. doi: 10.1182/blood-2009-03-212837. Epub 2009Jun 2. PubMed PMID: 19491390.

5: Spalton JC, Mori J, Pollitt AY, Hughes CE, Eble JA, Watson SP. Thenovel Syk inhibitor R406 reveals mechanistic differences in theinitiation of GPVI and CLEC-2 signaling in platelets. J Thromb Haemost.2009 Jul;7(7):1192-9. doi: 10.1111/j.1538-7836.2009.03451.x. Epub 2009Apr 24. PubMed PMID: 19422460.

6: Zhu Y, Herlaar E, Masuda ES, Burleson GR, Nelson AJ, Grossbard EB,Clemens GR. Immunotoxicity assessment for the novel Spleen tyrosinekinase inhibitor R406. Toxicol Appl Pharmacol. 2007 Jun15;221(3):268-77. Epub 2007 Mar 31. PubMed PMID: 17490694.

7: Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K,Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A,Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES. R406, anorally available spleen tyrosine kinase inhibitor blocks fc receptorsignaling and reduces immune complex-mediated inflammation. J PharmacolExp Ther. 2006 Dec;319(3):998-1008. Epub 2006 Aug 31. PubMed PMID:16946104.

品牌介绍
MedKoo,由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区(Research Triangle Park, 简称 RTP ),是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司,该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司,高校,研究院所,政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。
中文名MedKoo中    文美帝药库医药科技公司创立于2008年总部位于美国东海岸
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