Crolibulin

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WARNING: This product is for research use only, not for human or veterinary use.

Description:Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.

Price and Availability

Crolibulin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 200831Name: CrolibulinCAS#: 1000852-17-4Chemical Formula: C18H17BrN4O3Exact Mass: 416.0484Molecular Weight: 417.26Elemental Analysis: C, 51.81; H, 4.11; Br, 19.15; N, 13.43; O, 11.50

Synonym:EPC2407; EPC 2407; EPC-2407; Crolibulin crinobulin.

IUPAC/Chemical Name:(R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile

InChi Key:JXONINOYTKKXQQ-CQSZACIVSA-N

InChi Code:InChI=1S/C18H17BrN4O3/c1-24-13-6-8(5-11(19)17(13)25-2)14-9-3-4-12(21)15(22)16(9)26-18(23)10(14)7-20/h3-6,14H,21-23H2,1-2H3/t14-/m1/s1

SMILES Code:N#CC1=C(N)OC2=C(C=CC(N)=C2N)[C@H]1C3=CC(OC)=C(OC)C(Br)=C3

Technical Data

Additional Information

References

1: Patil SA, Patil R, Pfeffer LM, Miller DD.Chromenes: potential new chemotherapeutic agents for cancer. Future Med Chem. 2013Sep;5(14):1647-60. doi: 10.4155/fmc.13.126. Review. PubMed PMID: 24047270.

2: Cai SX, Drewe J, Kemnitzer W. Discovery of 4-aryl-4H-chromenes aspotent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novelvascular disrupting agents. Anticancer Agents Med Chem. 2009 May;9(4):437-56.Review. PubMed PMID: 19442043.

3: Cai SX. Small molecule vascular disrupting agents: potential newdrugs for cancer treatment. Recent Pat Anticancer Drug Discov. 2007Jan;2(1):79-101. Review. PubMed PMID: 18221055.