IDN-1965

WARNING: This product is for research use only, not for human or veterinary use.

Description:IDN-1965 is a potent, broad-spectrum, irreversible caspase inhibitor. IDN-1965 is markedly effective at inhibiting Fas-mediated apoptosis by multiple routes of administration. The therapeutic potential of caspase inhibitors appears promising for the treatment of apoptosis-mediated liver injury based on potency and postinsult efficacy.

Price and Availability

IDN-1965 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 511221Name: IDN-1965CAS#: 204919-14-2Chemical Formula: C21H26FN3O5Exact Mass: 419.18565Molecular Weight: 419.45Elemental Analysis: C, 60.13; H, 6.25; F, 4.53; N, 10.02; O, 19.07

Synonym:IDN1965; IDN-1965; IDN 1965.

IUPAC/Chemical Name:3-((S)-2-(1,3-dimethyl-1H-indole-2-carboxamido)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid

InChi Key:GONUYDANRODTCF-IBYPIGCZSA-N

InChi Code:InChI=1S/C21H26FN3O5/c1-11(2)18(20(29)23-14(9-17(27)28)16(26)10-22)24-21(30)19-12(3)13-7-5-6-8-15(13)25(19)4/h5-8,11,14,18H,9-10H2,1-4H3,(H,23,29)(H,24,30)(H,27,28)/t14?,18-/m0/s1

SMILES Code:O=C(O)CC(NC([C@@H](NC(C(N1C)=C(C)C2=C1C=CC=C2)=O)C(C)C)=O)C(CF)=O

Technical Data

Additional Information

References

1: Hayakawa Y, Chandra M, Miao W, Shirani J, BrownJH, Dorn GW 2nd, Armstrong RC, Kitsis RN. Inhibition of cardiac myocyteapoptosis improves cardiac function and abolishes mortality in theperipartum cardiomyopathy of Galpha(q) transgenic mice. Circulation.2003 Dec 16;108(24):3036-41. Epub 2003 Nov 24. PubMed PMID: 14638549.

2: Matsushita T, Yagi T, Hardin JA, Cragun JD, Crow FW, Bergen HR 3rd,Gores GJ, Nyberg SL. Apoptotic cell death and function of cryopreservedporcine hepatocytes in a bioartificial liver. Cell Transplant.2003;12(2):109-21. PubMed PMID: 12797372.

3: Natori S, Higuchi H, Contreras P, Gores GJ. The caspase inhibitorIDN-6556 prevents caspase activation and apoptosis in sinusoidalendothelial cells during liver preservation injury. Liver Transpl. 2003Mar;9(3):278-84. PubMed PMID: 12619025.

4: Hoglen NC, Hirakawa BP, Fisher CD, Weeks S, Srinivasan A, Wong AM,Valentino KL, Tomaselli KJ, Bai X, Karanewsky DS, Contreras PC.Characterization of the caspase inhibitor IDN-1965 in a model ofapoptosis-associated liver injury. J Pharmacol Exp Ther. 2001May;297(2):811-8. PubMed PMID: 11303074.

5: Grobmyer SR, Armstrong RC, Nicholson SC, Gabay C, Arend WP, PotterSH, Melchior M, Fritz LC, Nathan CF. Peptidomimetic fluoromethylketonerescues mice from lethal endotoxic shock. Mol Med. 1999 Sep;5(9):585-94.PubMed PMID: 10551900; PubMed Central PMCID: PMC2230465.

6: Natori S, Selzner M, Valentino KL, Fritz LC, Srinivasan A, ClavienPA, Gores GJ. Apoptosis of sinusoidal endothelial cells occurs duringliver preservation injury by a caspase-dependent mechanism.Transplantation. 1999 Jul 15;68(1):89-96. PubMed PMID: 10428274.