ARQ-171

WARNING: This product is for research use only, not for human or veterinary use.

Description:ARQ-171 is a second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage.

Price and Availability

ARQ-171,is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 205947Name: ARQ-171CAS#: NONEChemical Formula: Exact Mass: Molecular Weight: Elemental Analysis:

Synonym:ARQ171; ARQ 171; ARQ-171

IUPAC/Chemical Name:NONE

Technical Data

Additional Information

References

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2: Reis F, Kido RY, Mesquita JA, Oshima MM, Montenegro MA. Megalencephalic leukoencephalopathy with subcortical cysts (MLC) - a case with clinical and magnetic resonance imaging (MRI) dissociation. Arq Neuropsiquiatr. 2015 Feb;73(2):171-2. doi: 10.1590/0004-282X20140206. PubMed PMID: 25742591.

3: McGovern G, Martin S, Jeffrey M, Bellworthy SJ, Spiropoulos J, Green R, Lockey R, Vickery CM, Thurston L, Dexter G, Hawkins SA, González L. Influence of breed and genotype on the onset and distribution of infectivity and disease-associatedprion protein in sheep following oral infection with the bovine spongiform encephalopathy agent. J Comp Pathol. 2015 Jan;152(1):28-40. doi: 10.1016/j.jcpa.2014.09.004. Epub 2014 Nov 27. PubMed PMID: 25435510.

4: Savarese LG, Ferreira-Neto GD, Herrero CF, Defino HL, Nogueira-Barbosa MH. Cauda equina redundant nerve roots are associated to the degree of spinal stenosis and to spondylolisthesis. Arq Neuropsiquiatr. 2014 Oct;72(10):782-7. PubMed PMID: 25337731.

5: Andrade-Silva SG, Caranti DA, Sallet JA, Leal LP, Leal AJ, Dâmaso AR. Age andgender may influence the results of Roux-en-Y gastric bypass? Metabolic syndromeparameters. Arq Gastroenterol. 2014 Jul-Sep;51(3):171-9. PubMed PMID: 25296075.

6: Greenlee JJ, Kunkle RA, Richt JA, Nicholson EM, Hamir AN. Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculatedwith the agent of scrapie. PLoS One. 2014 Sep 18;9(9):e108029. doi: 10.1371/journal.pone.0108029. eCollection 2014. PubMed PMID: 25233232; PubMed Central PMCID: PMC4169493.

7: Secundo Junior JA, Santos MA, Faro GB, Soares CB, Silva AM, Secundo PF, Teixeira CK, Oliveira JL, Barreto Filho JA, Sousa AC. Left atrial volume index and prediction of events in acute coronary syndrome: Solar Registry. Arq Bras Cardiol. 2014 Oct;103(4):282-91. Epub 2014 Aug 13. English, Portuguese. Erratum in: Arq Bras Cardiol. 2014 Dec;103(6):546. PubMed PMID: 25119895; PubMed CentralPMCID: PMC4206358.

8: Abreu JS, Lima JW, Diógenes TC, Siqueira JM, Pimentel NL, Gomes Neto PS, Abreu ME, Paes Júnior JN. Coronary flow velocity reserve during dobutamine stress echocardiography. Arq Bras Cardiol. 2014 Feb;102(2):134-42. Epub 2013 Dec 21. PubMed PMID: 24676368; PubMed Central PMCID: PMC3987342.

9: González L, Pitarch JL, Martin S, Thurston L, Simmons H, Acín C, Jeffrey M. Influence of polymorphisms in the prion protein gene on the pathogenesis and neuropathological phenotype of sheep scrapie after oral infection. J Comp Pathol. 2014 Jan;150(1):57-70. doi: 10.1016/j.jcpa.2013.10.001. Epub 2013 Oct 10. PubMedPMID: 24342584.

10: Dozza AL, Krymchantowski AV. Adherence to migraine treatment does not dependon the number of prescribed medications. Arq Neuropsiquiatr. 2013 Mar;71(3):171-3. PubMed PMID: 23563717.