BPR1K653

WARNING: This product is for research use only, not for human or veterinary use.

Description:BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent activity against the growth of xenograft tumors of the human cervical carcinoma KB and KB-derived MDR1-positive KB-VIN10 cells in nude mice. Finally, BPR1K653 also exhibited favorable pharmacokinetic properties in rats., BPR1K653 is a promising anti-cancer compound that has potential for the management of various malignancies, particularly for patients with MDR1-related drug resistance after prolonged chemotherapeutic treatments.

Price and Availability

BPR1K653,is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406339Name: BPR1K653CAS#: 1192754-07-6 (BPR1K653 HCl salt) Chemical Formula: C30H29ClN6O2Exact Mass: 540.20405Molecular Weight: 541.04Elemental Analysis: C, 66.60; H, 5.40; Cl, 6.55; N, 15.53; O, 5.91

Synonym:BPR1K653; BPR1K 653; BPR1K-653.

IUPAC/Chemical Name:1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea

InChi Key:QBILDGGGAQXGGW-UHFFFAOYSA-N

InChi Code:InChI=1S/C30H29ClN6O2/c1-37(2)18-22-10-6-7-11-24(22)36-30(38)35-23-14-12-20(13-15-23)16-17-32-28-25-26(31)27(21-8-4-3-5-9-21)39-29(25)34-19-33-28/h3-15,19H,16-18H2,1-2H3,(H,32,33,34)(H2,35,36,38)

SMILES Code:O=C(NC1=CC=CC=C1CN(C)C)NC2=CC=C(CCNC3=C4C(OC(C5=CC=CC=C5)=C4Cl)=NC=N3)C=C2

Technical Data

Additional Information

  Related: 1192754-07-6 (BPR1K653 HCl salt) 1192754-06-5 (BPR1K653 free base).  

References

1: Cheung CH, Lin WH, Hsu JT, Hour TC, Yeh TK, Ko S,Lien TW, Coumar MS, Liu JF,  Lai WY, Shiao HY, Lee TR, Hsieh HP,Chang JY. BPR1K653, a novel Aurora kinase inhibitor, exhibits potentanti-proliferative activity in MDR1 (P-gp170)-mediatedmultidrug-resistant cancer cells. PLoS One. 2011;6(8):e23485. doi:10.1371/journal.pone.0023485. Epub 2011 Aug 24. PubMed PMID: 21887256;PubMed Central PMCID: PMC3160846.