Synonym:KU60019;KU60019;KU-60019.

IUPAC/ChemicalName:2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide.

InChiKey:SCELLOWTHJGVIC-BGYRXZFFSA-N

InChiCode:InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h4-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+

SMILESCode:O=C(NC1=CC(CC2=C(C(C3=CC(C=C(N4CCOCC4)O3)=O)=CC=C2)S5)=C5C=C1)CN6C[C@H](C)O[C@H](C)C6

TechnicalData

AdditionalInformation

References

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4:GoldingSE,RosenbergE,AdamsBR,WignarajahS,BecktaJM,O'ConnorMJ,ValerieK.DynamicinhibitionofATMkinaseprovidesastrategyforglioblastomamultiformeradiosensitizationandgrowthcontrol.CellCycle.2012Mar15;11(6):1167-73.doi:10.4161/cc.11.6.19576.Epub2012Mar15.PubMedPMID:22370485;PubMedCentralPMCID:PMC3335919.

5:GamperAM,ChoiS,MatsumotoY,BanerjeeD,TomkinsonAE,BakkeNISTCJ.ATMproteinphysicallyandfunctionallyinteractswithproliferatingcellnuclearantigentoregulateDNAsynthesis.JBiolChem.2012Apr6;287(15):12445-54.doi:10.1074/jbc.M112.352310.Epub2012Feb23.PubMedPMID:22362778;PubMedCentralPMCID:PMC3320994.

6:RasoA,VecchioD,CappelliE,RopoloM,PoggiA,NozzaP,BiassoniR,MascelliS,CapraV,KalfasF,SeveriP,FrosinaG.CharacterizationofgliomastemcellsthroughmultiplestemcellMarkersandtheirspecificsensitizationtodouble-strandbreak-inducingagentsbypharmacologicalinhibitionofataxiatelangiectasiamutatedprotein.BrainPathol.2012Sep;22(5):677-88.doi:10.1111/j.1750-3639.2012.00566.x.Epub2012Feb21.PubMedPMID:22257080.

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