MedKoo Biosciences/MPT0B098/406293/5g,MedKoo,,MedKoo Biosciences,MedKoo,美帝药库,MedKoo Biosciences试剂采购 MedKoo全国代理,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：MedKoo Biosciences/MPT0B098/406293/5g

产品编号：406293-5g

市场价：¥0.00

场地：美国(厂家直采)

产品分类：生化试剂>其他>其他试剂>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： MedKoo

公司：MedKoo Biosciences, Inc

公司分类：

商品介绍

MPT0B098isapotentmicrotubuleinhibitorthroughbindingtothecolchicine-bindingsiteoftubulin.MPT0B098isactiveagainstthegrowthofvarioushumancancercells,includingchemoresistantcellswithIC50valuesrangingfrom70to150nmol/L.MPT0B098arrestscellsintheG2Â–Mphaseandsubsequentlyinducescellapoptosis.Inaddition,MPT0B098effectivelysuppressesVEGF-inducedcellmigrationandcapillary-liketubeformationofHUVECs.Distinguishedfromothermicrotubuleinhibitors,MPT0B098notonlyinhibitedtheexpressionlevelsofHIF-1αproteinbutalsodestABIlizedHIF-1αmRNA.ThemechanismofcausingunstableofHIF-1αmRNAbyMPT0B098isthroughdecreasingRNA-bindingprotein,HuR,translocationfromthenucleustothecytoplasm.Notably,MPT0B098effectivelysuppressestumorgrowthandmicrovesseldensityoftumorspecimensinvivo.Takentogether,ourresultsprovideanovelmechanismofinhibitingHIF-1αofamicrotubuleinhibitorMPT0B098.MPT0B098isapromisinganticancerdrugcandidatewithpotentialforthetreatmentofhumanmalignancies.(source:MolCancerTher;2013,12(7);1202Â–12.

MedKooCat#:406293
Name:MPT0B098
CAS#:1254363-89-7
ChemicalFormula:C20H18N2O3S
ExactMass:366.10381
MolecularWeight:366.43
ElementalAnalysis:C,65.55;H,4.95;N,7.64;O,13.10;S,8.75

Synonym:MPT0B098.

IUPAC/ChemicalName:1-((4-methoxyphenyl)sulfonyl)-7-(pyridin-4-yl)indoline

InChiKey:AGYCYVPAEQVWJT-UHFFFAOYSA-N

InChiCode:InChI=1S/C20H18N2O3S/c1-25-17-5-7-18(8-6-17)26(23,24)22-14-11-16-3-2-4-19(20(16)22)15-9-12-21-13-10-15/h2-10,12-13H,11,14H2,1H3

SMILESCode:O=S(N1CCC2=C1C(C3=CC=NC=C3)=CC=C2)(C4=CC=C(OC)C=C4)=O

TechnicalData

Appearance:

Solidpowder

Purity:

>98%

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>5yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

AdditionalInformation

References

1:ChengYC,LiouJP,KuoCC,LaiWY,ShihKH,ChangCY,PanWY,TsengJT,Chang JY.MPT0B098,aNovelMicrotubuleInhibitorThatDestabilizestheHypoxia-InducIBLeFactor-1αmRNAthroughDecreasingNuclear-CytoplasmicTranslocationofRNA-BindingProteinHuR.MolCancerTher.2013Jul;12(7):1202-12.doi:10.1158/1535-7163.MCT-12-0778.Epub2013Apr25.PubMedPMID:23619299.

品牌介绍

MedKoo，由化学家和药学家陈清奇博士。北卡罗莱纳州的研究三角区（Research Triangle Park, 简称 RTP )，是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司，该公司的业务范围主要是为全球所有从事抗癌药物研究和开发的制药公司，高校，研究院所，政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。

中文名MedKoo中文美帝药库医药科技公司创立于2008年总部位于美国东海岸

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