Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was approved by FDA in November 20, 2008.

MedKoo Cat#: 201240 Name: Eltrombopag free base CAS#: 496775-61-2 (free base) Chemical Formula: C25H22N4O4 Exact Mass: 442.16411 Molecular Weight: 442.47 Elemental Analysis: C, 67.86; H, 5.01; N, 12.66; O, 14.46

Related CAS #: 496775-61-2 (free base) 496775-62-3 (olamine)

Synonym: SB497115; SB-497115; SB 497115; SB497115GR; Eltrombopag; Brand name: PROMACTA

IUPAC/Chemical Name: 3-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2-hydroxy-[1,1-biphenyl]-3-carboxylic acid

InChi Key: XDXWLKQMMKQXPV-QYQHSDTDSA-N

InChi Code: InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-

SMILES Code: O=C(C1=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O

Technical Data

Appearance: Red solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Certificate of Analysis: View current batch of CoA, Lot#TZC31214

QC Data: View QC data: current batch, Lot#TZC31214

Safety Data Sheet (MSDS): View Material Safety Data Sheet (MSDS)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code: 293490

Additional Information

Related CAS# 496775-61-2 (Eltrombopag free base); 496775-62-3 (Eltrombopag olamine).  

References

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