Hypocrellin B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by increasing ROS levels, and damaging cell walls. Price and Availability

Hypocrellin B,purity 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. 3-acetyl-6,11-dihydroxy-4,8,9,13-tetramethoxy-2-methyl-1H-cyclohepta[ghi]perylene-5,12-dioneInChi Key: KPGRZWCQXQUGHK-UHFFFAOYSA-NInChi Code: InChI=1S/C30H24O9/c1-10-7-13-20-19-12(26(33)28(35)29(13)38-5)8-15(36-3)22-16(37-4)9-14(32)21(24(19)22)25-23(20)17(10)18(11(2)31)30(39-6)27(25)34/h8-9,32H,7H2,1-6H3,(H,33,35)SMILES Code: O=C1C(OC)=C(C(C)=O)C2=C(C)CC(C3=C4C(C=C(OC)C5=C(OC)C=C(O)C(C1=C23)=C54)=C6O)=C(OC)C6=O Technical Data Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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3: Jiang Y, Leung AW, Wang X, Zhang H, Xu C. Effect of photodynamic therapy with hypocrellin B on apoptosis, adhesion, and migration of cancer cells. Int J Radiat Biol. 2014 Jul;90(7):575-9. doi: 10.3109/09553002.2014.906765. Epub 2014 Apr 23. PubMed PMID: 24661233.

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5: Jiang Y, Leung AW, Wang X, Zhang H, Xu C. Inactivation of Staphylococcus aureus by photodynamic action of hypocrellin B. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):600-6. doi: 10.1016/j.pdpdt.2013.06.004. Epub 2013 Aug 5. PubMed PMID: 24284117.

6: Kong M, Chen Z, Yin Z, Zhang J. [Simultaneous determination of hypocrellin A, hypocrellin B, and hypocrellin C by HPLC]. Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(1):75-8. Chinese. PubMed PMID: 22741466.

7: Galinato MG, Fogle RS 3rd, Galan JF. Binding interaction of hypocrellin B to myoglobin: a spectroscopic and computational study. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov;115:337-44. doi: 10.1016/j.saa.2013.06.052. Epub 2013 Jun 27. PubMed PMID: 23851176.

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9: Li T, Hou X, Deng H, Zhao J, Huang N, Zeng J, Chen H, Gu Y. Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo. Photochem Photobiol Sci. 2015 May;14(5):972-81. doi: 10.1039/c4pp00412d. PubMed PMID: 25793654.

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11: Jiang Y, Xia X, Leung AW, Xiang J, Xu C. Apoptosis of breast cancer cells induced by hypocrellin B under light-emitting diode irradiation. Photodiagnosis Photodyn Ther. 2012 Dec;9(4):337-43. doi: 10.1016/j.pdpdt.2012.03.009. Epub 2012 May 29. PubMed PMID: 23200015.

12: Chang JE, Cho HJ, Yi E, Kim DD, Jheon S. Hypocrellin B and paclitaxel-encapsulated hyaluronic acid-ceramide nanoparticles for targeted photodynamic therapy in lung cancer. J Photochem Photobiol B. 2016 May;158:113-21. doi: 10.1016/j.jphotobiol.2016.02.035. Epub 2016 Mar 3. PubMed PMID: 26967521.

13: Zhang J, Yan H, Chen Y, Chen R, He Y, Liu W. Efficient Degradation of Aqueous Rhodamine B Irradiation Under Indoor Light Using a SiO2 -Hypocrellin B Complex. Photochem Photobiol. 2016 Jul;92(4):644-8. doi: 10.1111/php.12596. Epub 2016 Jun 6. PubMed PMID: 27135189.

14: Zhou Z, Li Q, Liu W, Zhang L, Wang X, Ma H, Sheng W, Li Z, Zeng Y, Zhong R. Photo-killing mechanism of 2-demethoxy-2,3-ethylenediamino hypocrellin B (EDAHB) to HeLa cells. J Photochem Photobiol B. 2012 Dec 5;117:47-54. doi: 10.1016/j.jphotobiol.2012.08.014. Epub 2012 Sep 15. PubMed PMID: 23037979.

15: Jia Y, Wang X, Liu Q, Leung AW, Wang P, Xu C. Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathway. Ultrasonics. 2017 Jan;73:154-161. doi: 10.1016/j.ultras.2016.09.013. Epub 2016 Sep 13. PubMed PMID: 27657480.

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17: Zhou Z, Liu Y, Qin M, Sheng W, Wang X, Li Z, Zhong R. Depletion of PKM2 leads to impaired glycolysis and cell death in 2-demethoxy-2,3-ethylenediamino hypocrellin B-photoinduced A549 cells. J Photochem Photobiol B. 2014 May 5;134:1-8. doi: 10.1016/j.jphotobiol.2014.03.014. Epub 2014 Apr 2. PubMed PMID: 24792468.

18: Bai D, Xia X, Yow CM, Chu ES, Xu C. Hypocrellin B-encapsulated nanoparticle-mediated rev-caspase-3 gene transfection and photodynamic therapy on tumor cells. Eur J Pharmacol. 2011 Jan 15;650(2-3):496-500. doi: 10.1016/j.ejphar.2010.10.017. Epub 2010 Oct 21. PubMed PMID: 20970418.

19: Paramaguru G, Solomon RV, Venuvanalingam P, Renganathan R. Spectroscopic studies on TiO(2) enhanced binding of Hypocrellin B with DNA. J Fluoresc. 2011 Sep;21(5):1887-95. doi: 10.1007/s10895-011-0885-4. Epub 2011 Mar 30. PubMed PMID: 21448702.

20: Wang P, Xu CS, Xu J, Wang X, Leung AW. Hypocrellin B enhances ultrasound-induced cell death of nasopharyngeal carcinoma cells. Ultrasound Med Biol. 2010 Feb;36(2):336-42. doi: 10.1016/j.ultrasmedbio.2009.09.007. Epub 2009 Dec 16. PubMed PMID: 20018428.